Genome Instability and Bleomycin Sensitivity Test

Genome Instability and γH2AX

γH2AX has emerged in the last 20 years as a central player in the DDR (DNA damage response), with specificity for DSBs (double-strand breaks). Upon the generation of DSBs, γ-phosphorylation extends along megabase-long domains in chromatin, both sides of the damage. The significance of this mechanism is of great importance; it depicts a biological amplification mechanism where one DSB induces th...

Genome Instability and Aging

Genome Instability

Maintaining genomic stability in the face of replication and recombination requires a huge variety of different damage response proteins. A cell’s ability to decide when and where to deploy this DNA repair kit is critical to prevent tumor development. This issue’s Select highlights recent studies that help to explain how these difficult decisions are made and reveals that some surprising cellul...

Genome Instability

To whet your appetite for the special focus in next issue’s Leading Edge on Genomic Instability, we take a look at what’s new in the field of DNA repair. Ranging from network analyses of the proteins involved in mutagenic DNA repair to examination of single molecules taking part in homologous recombination, this Select probes the inner workings of a process that can wreak havoc during carcinoge...

intercultural sensitivity instruction and interfaces among iranian efl learners intercultural sensitivity,language proficiency,ehnic and demograhic backgrounds:an ethnocentrism vs.ethnorelativism perspective

monumental changes occurring on a daily basis have altered the world into a global village of expanding technology and shrinking geography in which preparing language learners for intercultural communication seems to be a sine qua non for modern language education. employing a cross-sectional design in its first phase, this study investigated the intercultural sensitivity and language proficien...